Circuit model of primary motor cortex

Primary motor cortex (M1) is the main origin of corticospinal and corticonuclear efferents. M1 is also the place where proprioceptive information – the position sense – and the premotor plan converge. Furthermore, M1 receives input from the thalamus, which in turn mediates signals from the cerebellum and from the basal ganglia. In order to understand how M1 integrates these different sources of information, we have to know about the microarchitecture of M1. The goal of my project is to construct a biologically realistic spiking model which is able to generate the precision grip.


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